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Titan Krios G4
E-CFEG, Selectris, Falcon4i

The Titan Krios G4 with Cold-FEG, Selectris energy filter, and Falcon IV detector: Solve structures at record-breaking resolutions

The 300kV Titan Krios G4 Cryo-TEM with the Thermo Scientific E-CFEG and the groundbreaking Thermo Scientific Selectris Imaging Filters to advance cryo-EM discovery with unprecedented resolution, speed, and ease of use.

The E-CFEG is a cold field emission gun with a narrow energy spread that results in higher contrast images and enables atomic resolution. This add-on makes it possible to efficiently solve structures at resolutions of 2.0 Å or less.

Selectris Imaging Filters provide unique stability, accessibility, and performance. Paired with the Thermo Scientific Falcon 4 Direct Electron Detector, these two add-ons produce better quality images up to 10 times faster than the previous generation.

Instrument Parameters

  • Accelerating Voltage
    80 … 300 kV
  • Electron Source
    E-CFEG (Cold FEG)
  • Stage Tilt Range
    ± 70°
  • C1 Apertures
    2000, 70, 50 and 30 µm
  • C2 Apertures
    150, 100, 50 and 20 µm
  • Objective Apertures
    100, 70 and 30 µm
  • Operating Temperature
    ~80 K
  • Information Limit at 300kV at 0° / ±70°
    0.12 nm / 0.23 nm
  • Cs
    2.7 mm
  • Number of cartridge positions for grids
    12 total
  • Sample exchange time
    ~3 mins from autoloader cassette to column
  • Camera
    Falcon4i
  • Camera pixels
    14 micrometer pixel size, 4096x4096 pixels, Electron Event Recording capable
  • Camera Performance DQE (1/2 Nyquist)
    0.70
  • Information Limit
    at 300kV at 0° / ±70° tilt 0.12 nm / 0.23 nm