Leica THUNDER Imager EM Cryo CLEM

Cryo-Correlative Light and Electron Microscope that bridges light and electron microscopy, allowing for dynamic imaging and precise localization studies in combination with high-resolution cryo-EM. Ideal for workflows that combine cellular context with structural detail.

Instrument Parameters


  • Camera
    Leica DFC9000 GT CMOS camera, high sensitivity, fast frame rate
  • Light Source
    HXP (High-Pressure Xenon) lamp for broad-spectrum fluorescence excitation
  • Objectives
    Leica HCX PL APO 50× (NA 0.90)
  • Filters
    DAPI (~358 nm excitation / ~461 nm emission)
    GFP (~488 nm excitation / ~509 nm emission)
    RFP (~555 nm excitation / ~584 nm emission)
  • Cryo Compatibility
    Dedicated cryo stage and sample holders to maintain vitrified conditions
  • Imaging Features
    Fast image acquisition to minimize devitrification risk
  • Software
    Leica Application Suite X (LAS X) for acquisition and analysis